Journal Articles (Read in Google Scholar)

  1. Stewart, S., Ou, W., Aranda-Espinoza, H., Rahaman, S.O., and He, X. Micromechanical characterizations and viscoelastic modeling reveal elastic and viscoelastic heterogeneities in ovarian tissue and the significant viscoelastic contribution to the apparent elastic modulus determined by AFM indentation. Acta Biomaterialia 2023; 168: 286-297 Read

  1. Lee, P.-C., Stewart, S., Amelkina, O., Sylvester, H., He, X., and Comizzoli, P. Trehalose delivered by cold-responsive nanoparticles improves tolerance of cumulus-oocyte complexes to microwave-drying. Journal of Assisted Reproduction and Genetics 2023; 40: 1817-1828 Read

  1. Ou, W., Stewart, S., White, A., Kwizera, E., Xu, J., Fang, Y., Shamul, J., Xie, C., Nurudeen, S., Tirada, N., Lu, X., Tkaczuk, K., and He, X. In-situ cryo-immune engineering of tumor microenvironment with cold-responsive nanotechnology for cancer immunotherapy. Nature Communications 2023; 14: 392 Read

  1. Levy, D., Jeyaram, A., Born, L.J., Chang, K.-H., Abadchi, S. N., Hsu, A., Solomon, T., Aranda, A., Stewart, S., He, X., Harmon, J.W., and Jay, S.M. The impact of storage condition on function of native and cargo-loaded mesenchymal stromal cell extracellular vesicles. Cytotherapy 2022; Read

  1. Kwizera, E.A., Ou, W., Lee, S., Stewart, S., Shamul, J.G., Xu, J., Tait, N., Tkaczuk, K., and He, X. Greatly enhanced CTC culture enabled by capturing CTC heterogeneity using a PEGylated PDMS-titanium-gold electromicrofluidic device with glutathione-controlled gentle cell release. ACS Nano 2022; 16: 11374–11391 Read

  1. Comizzoli, P., He, X., and Lee, P. Long-term preservation of germ cells and gonadal tissues at ambient temperatures. Reproduction and Fertility 2022; 3: R42-R50 Read

  1. Jiang, B., White, A., Ou, W., Van Belleghem, S., Stewart, S., Shamul, J.G., Rahaman, S.O., Fisher, J.P., and He, X. Noncovalent reversible binding-enabled facile fabrication of leak-free PDMS microfluidic devices without plasma treatment for convenient cell loading and retrieval. Bioactive Materials 2022; 16: 346-358 Read

  1. Xu, J., Shamul, J.G., Kwizera, E.A., and He, X. Recent advancements in mitochondria-targeted nanoparticle drug delivery for cancer therapy. Nanomaterials 2022; 12: 743 Read

  1. Xu, J., Liu, Y., Liu, S., Ou, W., White, A., Stewart, S., Tkaczuk, K.H.R., Ellis, L.M., Wan, J., Lu, X., and He, X. Metformin bicarbonate-mediated efficient RNAi for precise targeting of TP53 deficiency in colon and rectal cancers. Nano Today 2022; 43: 101406 Read

  1. Kwizera, E.A., Stewart, S., Mahmud, M.M., and He, X. Magnetic nanoparticle-mediated heating for biomedical applications. Journal of Heat Transfer-Transactions of the ASME 2022; 144: 030801 Read

  1. Dumbleton, J., Shamul, J.G., Jiang, B., Agarwal, P., Huang, H., Jia, X., and He, X. Oxidation and RGD modification affect the early neural differentiation of murine embryonic stem cells cultured in core-shell alginate hydrogel microcapsules. Cells Tissues Organs 2022; 211: 22-31 Read

  1. Jiang, B., Ou, W., Shamul, J.G., Chen, H., Van Belleghem, S., Stewart, S., Liu, Z., Fisher, J.P., and He, X. Rock inhibitor may compromise human induced pluripotent stem cells for cardiac differentiation in 3D. Bioactive Materials 2022; 9: 508-522 Read

  1. Huang, H., He, X., and Yarmush, M.L. Advanced technologies for the preservation of mammalian biospecimens. Nature Biomedical Engineering 2021; 5: 793-804 Read

  1. Zhu, Q., Hao, H., Xu, H., Fichman, Y., Cui, Y., Yang, C., Wang, M., Mittler, R., Hill, M.A., Cowan, P.J., Zhang, G., He, X., Zhou, S., and Liu, Z. Combination of antioxidant enzyme overexpression and n-acetylcysteine treatment enhances the survival of bone marrow mesenchymal stromal cells in ischemic limb in mice with type 2 diabetes. Journal of the American Heart Association 2021; 10: e023491 Read

  1. Van Belleghem, S., Mahadik, B., Snodderly, K., Mote, Z., Jiang, B., Yu, J., McLoughlin, S., He, X., Nam, A.J., Fisher, J.P. Dual extrusion patterning drives tissue development aesthetics and shape retention in 3D printed nipple‐areola constructs. Advanced Healthcare Materials 2021; 10: 2101249 Read

  1. Xu, J., Shamul, J.G., Staten, N.A., White, A.M., Jiang, B., and He, X. Bioinspired 3D culture in nanoliter hyaluronic acid-rich core-shell hydrogel microcapsules isolates highly pluripotent human iPSCs. Small 2021; 17: 2102219 Read

  1. Zhou, Z., Van der Jeught, K., Fang, Y., Yu, T., Li, Y., Ao, Z., Liu, S., Zhang, L., Yang, Y., Eyvani, H., Cox, M.L., Wang, X., He, X., Ji, G., Schneider, B.P., Guo, F., Wan, J., Zhang, X., and Lu, X. An organoid-based screen for epigenetic inhibitors that stimulate antigen presentation and potentiate T-cell-mediated cytotoxicity. Nature Biomedical Engineering 2021; 5: 1320-1335 Read

  1. Jiang, B., Li, W., Stewart, S., Ou, W., Liu, B., Comizzoli, P., and He, X. Sand-mediated ice seeding enables serum-free low-cryoprotectant cryopreservation of human induced pluripotent stem cells. Bioactive Materials 2021; 6: 4377-4388 Read

  1. Kwizera, E.A., Sun, M., White, A., Li, J., and He, X. Methods of generating dielectrophoretic force for microfluidic manipulation of bioparticles. ACS Biomaterials Science & Engineering 2021; 7: 2403-2063 Read

  1. White, A.M., Zhang, Y., Shamul, J.G., Xu, J., Kwizera, E.A., Jiang, B., and He, X. Deep learning-enabled label-free on-chip detection and selective extraction of cell aggregate-laden hydrogel microcapsules. Small 2021; 17: 2100491 Read

  1. Chen, H., Jiang, B., Shamul, J.G., and He, X. Image entropy-based label-free functional characterization of human induced pluripotent stem cell-derived 3D cardiac spheroids. Biosensors and Bioelectronics 2021; 179: 113055 Read

  1. Xu, H., Van der Jeught, K., Zou, Z., Zhang, L., Yu, T., Sun, Y., Li, Y., Wan, C., So, K.M., Liu, D., Frieden, M., Fang, Y., Mosley, A.L., He, X., Zhang, X., Sandusky, G.E., Liu, Y., Meroueh, S.O., Zhang, C., Wijeratne, A.B., Huang, C., Ji, G., and Lu, X. Atractylenolide I enhances responsiveness to immune checkpoint blockade therapy by activating tumor antigen presentation. Journal of Clinical Investigation 2021; 131: e146832 Read

  1. Yang, G., Mahadik, B., Choi, J.Y., Yu, J.R., Mollot, T., Jiang, B., He, X., Fisher, J.P. Fabrication of centimeter-sized 3D constructs with patterned endothelial cells through assembly of cell-laden microbeads as a potential bone graft 3D Tissue constructs with patterned vasculature through cell-laden microbead. Acta Biomaterialia 2021; 121: 204-213 Read

  1. Wang, H., Liang, Y., Yin, Y., Zhang, J., Su, W., White, A.M., Jiang, B., Xu, J., Zhang, Y., Stewart, S., Lu, X., and He, X. Carbon nano-onion-mediated dual targeting of P-selectin and P-glycoprotein to overcome cancer drug resistance. Nature Communications 2021; 12: 312 Read

  1. Stewart, S., Arminan, A., and He, X. Nanoparticle-mediated delivery of cryoprotectant for cryopreservation. CryoLetters 2020; 41: 308-316 Read

  1. Xu, J., Shamul, J.G., Wang, H., Lin, J., Agarwal, P., Sun, M., Lu, X., Tkaczuk, K.H.R., and He, X. Targeted heating of mitochondria greatly augments nanoparticle-mediated cancer chemotherapy. Advanced Healthcare Materials 2020; 9: 2000181 Read

  1. Cui, Y., Liu, L., Xiao, Y., Li, X., Zhang, J., Xie, X., Tian, J., Sen, C.K., He, X., Hao, H., and Liu, Z. N-acetylcysteine differentially regulates the populations of bone marrow and circulating endothelial progenitor cells in mice with limb ischemia. European Journal of Pharmacology 2020; 881: 173233  Read

  1. Wang, H., Agarwal, P., Jiang, B., Stewart, S., Liu, X., Liang, Y., Hancioglu, B., Webb, A., Fisher, J.P., Liu, Z., Lu, X., Tkaczuk, K.H.R., and He, X. Bioinspired one cell culture isolates highly tumorigenic and metastatic cancer stem cells capable of multilineage differentiation. Advanced Science 2020; 7: 2000259 Read

  1. Xiao, Y., Zhu, Q., Liu, X., Jiang, M., Hao, H., Zhu, H., Cowan, P.J., He, X., Liu, Q., Zhou, S., and Liu, Z. High fat diet selectively decreases bone marrow lin-/CD117+ cell population in aging mice through increased ROS production.  Journal of Tissue Engineering and Regenerative Medicine 2020; 14: 884-892  Read

  1. White, A.M., Shamul, J.G., Xu, J., Stewart, S., Bromberg, J.S., and He, X. Engineering strategies to improve islet transplantation for type 1 diabetes therapy. ACS Biomaterials Science & Engineering 2020; 6: 2543-2562  Read

  1. Van der jeught, K., Sun, Y., Fang, Y., Zhou, Z., Jiang, H., Yu, T., Yang, J., Kamocka, M.M., So, K.M., Li, Y., Eyvani, H., Sandusky, G.E., Frieden, M., Braun, H., Beyaert, R., He, X., Zhang, X., Zhang, C., Paczesny, S., and Lu, X. ST2 as checkpoint target for colorectal cancer immunotherapy. JCI Insight 2020; 5: e136073 Read


  1. Jiang, B., Yan, L., Shamul, J.G., Hakun, M., and He, X. Stem cell therapy of myocardial infarction: a promising opportunity in bioengineering. Advanced Therapeutics 2020; 3: 1900182 Read

  1. Hou, Y., Sun, X., Yao, S., Rao, W., and He, X. Cryoablation-activated enhanced nanodoxorubicin release for the therapy of chemoresistant mammary cancer stem-like cells. Journal of Materials Chemistry B 2020; 8: 908-918 Read

  1. Zhang, Y., Wang, H., Stewart, S., Jiang, B., Ou, W., Zhao, G., and He, X. Cold-Responsive nanoparticle enables intracellular delivery and rapid release of trehalose for organic solvent-free cryopreservation. Nano Letters 2019; 19: 9051-9061 Read

  1. Xu, J., Liu, Y., Li, Y., Wang, H., Stewart, S., Van der Jeught, K., Agarwal, P., Zhang, Y., Liu, S., Zhao, G., Wan, J., Lu, X., and He, X. Precise targeting of POLR2A as a therapeutic strategy for human triple negative breast cancer. Nature Nanotechnology 2019; 14: 388-397 Read

  1. Sun, M., Xu, J, Shamul, J.G., Lu, X., Husain, S., and He, X. Creating a capture zone in microfluidic flow greatly enhances the throughput and efficiency of cancer detection. Biomaterials 2019; 197: 161-170 Read

  1. Cao, Y., Zhao, G., Panhwar, F., Zhang, X., Chen, Z., Cheng, L., Zang, C., Liu, F., Zhao, Y., and He, X. The unusual properties of polytetrafluoroethylene enable massive-volume vitrification of stem cells with low-concentration cryoprotectants. Advanced Materials Technologies 2019; 4: 1800289 Read

  1. Stewart, S. and He, X. Intracellular delivery of trehalose for cell banking. Langmuir 2019; 35: 7414-7422 Read

  1. Liu, Y., Xu, J, Choi, H.H., Han, C., Fang, Y., Li, Y., Van der Jeught, K., Xu, H., Zhang, L., Frieden, M., Wang, L., Eyvani, H., Sun, Y., Zhao, G., Zhang, Y., Liu, S., Wan, J., Huang, C., Ji, G., Lu, X., He, X., and Zhang, X. Targeting 17q23 amplicon to overcome the resistance to anti-HER2 therapy in HER2+ breast cancer. Nature Communications 2018; 9: 4718 Read

  1. Li, Y., Liu, Y., Xu, H., Jiang, G., Van der Jeught, K., Fang, Y., Zhou, Z., Zhang, L., Frieden, M., Wang, L., Luo, Z., Radovich, M., Schneider, B.P., Deng, Y., Liu, Y., Huang, K., He, B., Wang, J., He, X., Zhang, X., Ji, G., and Lu, X. Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to the Inhibition of RNA polymerase II. Nature Communications 2018; 9: 4394 Read

  1. Wang, Y., Chu, J., Yi, P., Dong, W., Saultz, J.N., Wang, Y., Wang, H., Scoville. S.D., Zhang, J., Wu, L.C., Deng, Y., He, X., Mundy-Bosse, B.L., Freud, A.G., Wang, L.S., Caligiuri, M.A., and Yu. J. SMAD4 promotes TGF-β-independent NK cell homeostasis and maturation and antitumor immunity. Journal of Clinical Investigation 2018; 128: 5123-5136 Read

  1. Wang, H., Agarwal, P., Liang, Y., Xu, J., Zhao, G.,Tkaczuk, K.H.R., Lu, X., and He, X. Enhanced cancer therapy with cold-controlled drug release and photothermal warming enabled by one nanoplatform. Biomaterials 2018; 180: 265-278 Read

  1. Liu, X., Zhao, G., Chen, Z., Panhwar, F., and He, X. Dual suppression effect of magnetic induction heating and microencapsulation on ice crystallization enables low-cryoprotectant vitrification of stem cell-alginate hydrogel constructs. ACS Applied Materials & Interfaces 2018; 10: 16822-16835 Read

  1. Choi, J.K. and He, X. A simple and fast method for derivation of blastocyst-like cell aggregates (BLCAs) from murine embryonic stem cells. Journal of Biomaterials and Tissue Engineering  2018; 8: 1004-1009 Read

  1. Liu, Y., Xu, H., Van der Jeught, K., Li, Y., Liu, S., Zhang, L., Fang, Y., Zhang, X., Rodovich, M., Schneider, B., He, X., Huang, C., Zhang, C., Wan, J., Ji, G., and Lu, X. Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in human cancer. Journal of Clinical Investigation 2018; 128: 2951-2965 Read

  1. Wang, H., Agarwal, P., Zhao, G., Ji, G., Jewell, C.M., Fisher, J.P., Lu, X., and He, X. Overcoming ovarian cancer drug resistance with a cold responsive nanomaterial. ACS Central Science 2018; 4: 567–581 Read

  1. Wang, H., Gao, Zan., Liu, X., Agarwal, P., Zhao, S., Conroy, D., Ji, G., Yu, J., Jaroniec, C., Liu, Z., Lu, X., Li, X., and He, X. Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance. Nature Communications 2018; 9: 562 Read

  1. Li, X., Dong, W., Nalin, A., Wang, Y., Pan, P.,  Xu, Bo.,  Zhang, Y., Tun, S., Zhang, J.,  Wang, L., He, X., Caligiuri, M., and Yu, J. The natural product chitosan enhances the anti-tumor activity of natural killer cells by activating dendritic cells. OncoImmunology 2018; 7: e1431085 Read

  1. Sun, M., Durkin, P., Li, J., Toth, T., and He, X. Label-free on-chip selective extraction of cell aggregate-laden microcapsules from oil into aqueous solution with optical sensor and dielectrophoresis. ACS Sensors 2018; 3: 410-417 Read

  1. Zhao, G., Liu, X., Zhu, K., and He, X. Hydrogel encapsulation facilitates rapid-cooling cryopreservation of stem cell-laden core-shell microcapsules as cell-biomaterial constructs. Advanced Healthcare Materials 2017; 6: 1700988 Read

  1. Niu, Y., Zhang, X., Si, T., Zhang, Y., Qi, L., Zhao, G., Xu, R., He, X., and Zhao, Y. Simultaneous measurements of geometric and viscoelastic properties of hydrogel microbeads using continuous-flow microfluidics with embedded electrodes. Small 2017; 13: 1702821 Read

  1. Wang, H., Agarwal, P., Xiao, Y., Peng, H., Zhao, S., Liu, X., Zhou, S., Li, J., Liu, Z., and He, X. A nano-in-micro system for enhanced stem cell therapy of ischemic diseases. ACS Central Science 2017; 3: 875-885 Read

  1. Agarwal, P.^, Wang, H.^, Sun, M., Xu, J., Zhao, S., Liu, Z., Gooch, K.J., Zhao, Y., Lu, X., and He, X. Microfluidics-enabled bottom-up engineering of 3D microvascularized human tumor for drug discovery. ACS Nano 2017; 11: 6691-6702 (^equal contribution) Read

  1. Huang, H., Zhao, G., Zhang, Y., Xu, J., Toth, T.L., and He, X. Predehydration and ice seeding in the presence of trehalose enable cell cryopreservation. ACS Biomaterials Science & Engineering 2017; 3: 1758-1768 Read

  1. Zhang, Y., Zhao, G., Hossain, S.M.C., and He, X. Modeling and experimental studies of enhanced cooling by medical gauze for cell cryopreservation by vitrification. International Journal of Heat and Mass Transfer 2017; 114: 1-7 Read

  1. Huang, H., Yu, Y., Hu, H., He, X., Usta, O.B., and Yarmush, M.L. Generation and manipulation of hydrogel microcapsules by droplet-based microfluidics for mammalian cell culture. Lab on a Chip 2017; 17: 1913-1932 Read

  1. Fullagar, B, Rao, W., Gilor, C., Xu, F., He, X., and Adin, C.A. Nano-encapsulation of bilirubin in Pluronic F127-chitosan nanoparticles improves uptake in beta cells and increases islet viability and function after hypoxic stress. Cell Transplantation 2017; 26: 1703-1715 Read

  1. He, X. Microfluidic encapsulation of ovarian follicles for 3D culture. Annals of Biomedical Engineering 2017; 45: 1676-1684 Read

  1. Zhao, G., Zhang, Z., Zhang, Y., Chen, Z., Niu, D., Cao, Y., and He, X. A microfluidic perfusion approach for on-chip characterization of the transport properties of human oocytes. Lab on a Chip 2017; 17:1297-1305 Read

  1. He, X. Microscale biomaterials with bioinspired complexity of early embryo development and in the ovary for tissue engineering and regenerative medicine. ACS Biomaterials Science & Engineering 2017; 3: 2692–2701 Read

  1. Zhang, X., Hossain, S.M.C., Zhao, G., Qiu, B., and He, X. Two-phase heat transfer model for multiprobe cryosurgery. Applied Thermal Engineering 2017; 113: 47-57 Read

  1. Zhang, W., Choi, J.K., and He, X. Engineering microvascularized 3D tissue using alginate-chitosan microcapsules. Journal of Biomaterials and Tissue Engineering 2017; 7: 170-173 Read

  1. He, X. and Toth, T.L. In vitro culture of ovarian follicles from Peromyscus. Seminars in Cell and Developmental Biology 2017; 61: 140-149 Read

  1. Zhao, S., Xu, Z., Wang, H., Reese, B., Gushchina, L., Jiang, M., Agarwal, P., Xu, J., Zhang, M., Shen, Y., Liu, Z., Weisleder, N., and He, X. Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction. Nature Communications 2016; 7: 13306 Read

  1. Zheng, Y., Zhao, G., Fazil Panhwar, F., and He, X. Vitreous cryopreservation of human umbilical vein endothelial cells with low concentration of cryoprotective agents for vascular tissue engineering. Tissue Engineering Part C 2016; 22: 964-973 Read

  1. Sun, M., Agarwal, P., Zhao, S., Zhao, Y., Lu, X., and He, X. Continuous on-chip cell separation based on conductivity-induced dielectrophoresis with 3D self-assembled ionic liquid electrodes. Analytical Chemistry 2016; 88: 8264-8271 Read

  1. Zhao, S.^, Zhang, L.^, Han, J., Chu, J., Wang, H., Chen, X., Wang, Y., Tun, N., Lu, L., Bai, X.-F., Martha, Y., Devine, S., He, X.*, and Yu, J.* Conformal nanoencapsulation of allogeneic T cells mitigates graft-versus-host disease and retains graft-versus-leukemia activity. ACS Nano 2016; 10: 6189-6200 (^equal contribution) (*co-corresponding authors) Read

  1. Sun, M.^, Kiourti, A.^, Wang, H., Zhao, S., Zhao, G., Lu, X., Volakis, J.L., and He, X. Enhanced microwave hyperthermia of cancer cells with fullerene. Molecular Pharmaceutics 2016; 13: 2184-2192 (^equal contribution) Read

  1. Wang, H, Agarwal, P., Zhao, S., Yu, J., Lu, X., and He, X. Combined cancer therapy with hyaluronan-decorated fullerene-silica multifunctional nanoparticles to target cancer stem-like cells. Biomaterials 2016; 97: 62-73 Read

  1. Chen, X., Han, J., Chu, J., Zhang, L., Zhang, J., Chen, C., Chen, L., Wang, Y., Wang, H., Yi, L., Elder, J.B., Wang, Q.-E., He, X., Kaur, B., Chiocca, E. A., and Yu, J. A combinational therapy of EGFR-CAR NK cells and oncolytic herpes simplex virus 1 for breast cancer brain metastases. Oncotarget 2016; 7: 27764-27777 Read

  1. Wang, J., Zhao, G., Zhang, Z., Xu, X., and He, X. Magnetic induction heating of superparamagnetic nanoparticles during rewarming augments the recovery of hUCM-MSCs cryopreserved by vitrification. Acta Biomaterialia 2016; 33: 264-274 Read

  1. Dumbleton, J., Agarwal, P., Huang, H., Hogrebe, N., Han, R., Gooch, K.J., and He, X. The effect of RGD peptide on 2D and miniaturized 3D culture of HEPM cells, MSCs, and ADSCs with alginate hydrogel. Cellular and Molecular Bioengineering 2016; 9: 277-288 Read

  1. Rao, W.^, Wang, H.^, Zhong, A.^, Yu, J., Lu, X., and He, X. Nanodrug-mediated thermotherapy of cancer stem-like cells. Journal of Nanoscience and Nanotechnology 2016; 16: 2134-2142 (^equal contribution) Read

  1. Si, T., Yin, C., Gao, P., Li, G., Ding, H., He, X., Xie, B., and Xu, R.X. Steady cone-jet mode in compound-fluidic electro-flow focusing for fabricating multicompartment microcapsules. Applied Physics Letters 2016; 108: ARTN 021601 Read

  1. Wang, H., Agarwal, P., Zhao, S., Yu, J., Lu, X., and He, X. A near infrared laser-activated “nanobomb” for breaking the barriers to microRNA delivery. Advanced Materials 2016; 28: 347-355 Read

  1. Wang, H., Yu, J., Lu, X., and He, X. Nanoparticle systems reduce systemic toxicity in cancer treatment. Nanomedicine 2016; 11: 103-106 Read
  2. Wang, H., Agarwal, P., Zhao, S., Yu, J., Lu, X., and He, X. A biomimetic hybrid nanoplatform for encapsulation and precisely controlled delivery of theranostic agents. Nature Communications 2015; 6: 10081 Read

  1. Han, J., Chen, X., Chu, J., Zhang, L., Meisen, W.H., Zhang, J., He, X., Wang, Q.-E., Chiocca, E.A., Kaur, B., Caligiuri, M.A., and Yu, J. TGF-beta treatment enhances glioblastoma virotherapy by inhibiting innate immune response. Cancer Research 2015; 75: 5273-5282 Read

  1. Liu, Y., Hu, X., Han, C., Wang, L., Zhang, X., He, X. and Lu, X. Targeting tumor suppressor genes for cancer therapy. BioEssays 2015; 37: 1277-1286 Read

  1. Huang, H.^, Choi, J.K.^, Rao, W., Zhao, S., Agarwal, P., Zhao, G., and He, X. Alginate hydrogel microencapsulation inhibits devitrification and enables large-volume low-CPA cell vitrification. Advanced Functional Materials 2015; 25: 6839-6850 (^equal contribution) Read

  1. Wang, H., Agarwal, P., Zhao, S., Xu, R.X., Yu, J., Lu, X., and He, X. Hyaluronic acid-decorated dual responsive nanoparticles of Pluronic F127, PLGA, and chitosan for targeted co-delivery of doxorubicin and irinotecan to eliminate cancer stem-like cells. Biomaterials 2015; 72: 74-89 Read

  1. Huang, H. and He, X. Fluid displacement during droplet formation at microfluidic flow-focusing junctions. Lab on a Chip 2015; 15: 4197-4205 Read

  1. Choi, J.K., Yue, T., Huang, H., Zhao, G., Zhang, M., and He, X. The crucial role of zona pellucida in cryopreservation of oocytes by vitrification. Cryobiology 2015; 71: 350-355 Read

  1. Huang, H.^, Sun, M.^, Heisler-Taylor, T., Kiourti, A., Volakis, J., Lafyatis, G., and He, X. Stiffness-independent highly efficient on-chip extraction of cell-laden hydrogel microcapsules from oil emulsion into aqueous solution by dielectrophoresis. Small 2015; 11: 5369-5374 (^equal contribution) Read

  1. Wang, Z., Zhao, G., Wang, T., Yu, Q., Su, M., and He, X. Three-dimensional numerical simulation of the effects of fractal vascular trees on tissue temperature and intracelluar ice formation during combined cancer therapy of cryosurgery and hyperthermia. Applied Thermal Engineering 2015; 90: 296-304 Read

  1. Choi, J.K. and He, X. Improved oocyte isolation and embryonic development of outbred deer mice. Scientific Reports 2015; 5:12232 Read

  1. Han, J., Chu, J., Chan, W.K., Zhang, J., Wang, Y., Cohen, J.B., Victor, A., Meisen, W.H., Kim, S.-H., Grandi, P., Wang, Q.-E., He, X., Nakano, I., Chiocca, E.A., Glorioso, J., Kaur, B., Caligiuri, M, and Yu, J. CAR-engineered NK cells targeting wild-type EGFR and EGFRvIII enhance killing of glioblastoma and patient-derived glioblastoma stem cells. Scientific Reports 2015; 5: 11483 Read

  1. Rao, W.^, Wang, H.^, Han, J., Zhao, S., Dumbleton, J., Agarwal, P., Zhang, W., Zhao, G., Yu, J., Zynger, D.L., Lu, X., and He, X. Chitosan-decorated doxorubicin-encapsulated nanoparticle targets and eliminates tumor reinitiating cancer stem-like cells. ACS Nano 2015; 9: 5725-5740 (^equal contribution) Read

  1. Agarwal, P.^, Choi, J.K.^, Huang, H., Zhao, S., Dumbleton, J., Li, J., and He, X. A biomimetic core-shell platform for miniaturized 3D cell and tissue engineering. Particle & Particle Systems Characterization 2015; 32: 809-816 (^equal contribution) Read

  1. Choi, J.K., Huang, H., and He, X. Improved low-CPA vitrification of mouse oocytes using quartz microcapillary. Cryobiology 2015; 70: 269-272 Read

  1. Wang, H., Zhao, S., Agarwal, P., Dumbleton, J., Yu, J., Lu, X., and He, X. Multi-layered polymeric nanoparticles for pH-responsive and sequenced release of theranostic agents. Chemical Communications 2015; 51: 7733-7736 Read

  1. Liu, Y., Zhang, X., Han, C., Wan, G., Huang, X., Ivan, C., Jiang, D., Rao, P.H., Maru, D.M., Pahl, A., He, X., Sood, A.K., Ellis, L.M., Anderl, J., and Lu, X. TP53 loss creates therapeutic vulnerability in colorectal cancer. Nature 2015; 520: 697-701 Read

  1. Zhang, W., Zhao, S., and He, X. Proliferation and differentiation of mesenchymal stem cells encapsulated in miniaturized 3D core of alginate-chitosan-alginate (ACA) microcapsules. Archives of Stem Cell Research 2015; 2: 1004-1009 Read

  1. Rao, W., Huang, H., Wang, H., Zhao, S., Dumbleton, J., Zhao, G., and He, X. Nanoparticle-mediated intracellular delivery enables cryopreservation of human adipose-derived stem cells using trehalose as the sole cryoprotectant. ACS Applied Materials & Interfaces 2015; 7: 5017–5028 Read

  1. Huang, H. and He, X. Interfacial tension based on-chip extraction of microparticles confined in microfluidic Stokes flows. Applied Physics Letters 2014; 105: Article No. 143704 (5 pp) Read

  1. Kiourti, A., Sun, M., He, X., and Volakis, J.L. Microwave cavity with controllable temperature for in vitro hyperthermia investigations. Journal of Electromagnetic Engineering and Science 2014; 14: 267-272 Read

  1. Han, C., Liu, Y., Wan, G., Choi, H.J., He, X., Zhao, L., Ivan, C., Sood, A.K., Zhang, X., and Lu, X. The RNA-binding protein DDX1 promotes primary microRNA maturation and inhibits ovarian tumor progression. Cell Reports 2014; 8: 1447-1460 Read

  1. Deng, Y., Ren, Y., Fan, Z., Chu, J., Ji, X., Yuan, S., He, S., Hughes, T., Zhang, J., Cheema, B., Camardo, A.T., Xia, Y., Wu, L.-C., He, X., Kinghorn, D., Li, X., Caligiuri, M.A., and Yu, J. The natural product phyllanthusmin C selectively enhances IFN-gamma production by human natural killer cells through upregulation of TLR-mediated NF-kB signaling. Journal of Immunology 2014; 193: 2994-3002 Read

  1. Zhao, S., Agarwal, P., Rao, W., Huang, H., Zhang, R., Liu, Z., Yu, J., Weisleder, N., Zhang, W., and He, X. Coaxial electrospray of liquid core-hydrogel shell microcapsules for encapsulation and miniaturized 3D culture of pluripotent stem cells. Integrative Biology 2014; 6: 874-884 Read

  1. Rao, W.^, Zhao, S.^, Yu, J., Lu, X., Zynger, D.L., and He, X. Enhanced enrichment of prostate cancer stem-like cells with miniaturized 3D culture in liquid core-hydrogel shell microcapsules. Biomaterials 2014; 35: 7762-7773 (^equal contribution) Read

  1. Yi, J., Liang, X.M., Zhao, G., and He, X. An improved model for nucleation-limited ice formation in living cells during freezing. PLoS ONE 2014; 9(5): e98132 Read

  1. Choi, J.K.^, Agarwal, P.^, Huang, H.^, Zhao, S., and He, X. The crucial role of mechanical heterogeneity in regulating follicle development and ovulation with engineered ovarian microtissue. Biomaterials 2014; 35: 5122-5128 (^equal contribution) Read

  1. Zhao, G., Takamatsu, H., and He, X. The effect of solution nonideality on modeling transmembrane water transport and diffusion-limited intracellular ice formation during cryopreservation. Journal of Applied Physics 2014; 115(14): 144701-13 Read

  1. Chu, J., He, S., Deng, Y., Zhang, J., Peng, Y., Devine, S.M., Kwon, C.-H., He, X., Bai, X.-F., Hofmeister, C.C., and Yu, J. Genetic modification of T cells redirected towards CS1 enhances anti-myeloma activity. Clinical Cancer Research2014; 20: 3899-3901 Read

  1. Rao, W., Zhang, W., Poventud-Fuentes, I., Wang, Y., Lei, Y., Agarwal, P., Weekes, B., Li, C., Lu, X., Yu, J., and He, X. Thermally responsive nanoparticle-encapsulated curcumin and its combination with mild hyperthermia for enhanced cancer cell destruction. Acta Biomaterialia 2014; 10: 831-842 Read

  1. He, S., Deng, Y., Vasu, S., Chu, J., Zhang, J., Fan, Z., He, X., Marsh, H., Devine, S. M., and Yu, J. FLT3L and Plerixafor combination increases hematopoietic stem cell mobilization and leads to improved transplantation outcome. Biology of Blood and Marrow Transplantation 2014; 20: 309-313 Read

  1. Rao, W., Bellotti, A., Littrup, P.J., Yu, J., Lu, X., and He, X. Nanoparticle-encapsulated doxorubicin enhances cryoablation of cancer stem-like cells. Technology 2014; 2: 28-35 Read

  1. Chu, J., Deng, Y., Benson, D. M. (Jr.), He, S., Hughes, T., Zhang, J., Peng, Y., Mao, H., Yi, L., Ghoshal, K., He, X., Devine, S. M., Zhang, X., Caligiuri, M.A., Hofmeister, C. C., and Yu, J. CS1-specific chimeric antigen receptor (CAR)-engineered natural killer cells enhance in vitro and in vivo anti-tumor activity against human multiple myeloma. Leukemia 2014; 28: 917-927 Read
  2. Choi, J.K., Agarwal, P., and He, X. In vitro culture of early secondary preantral follicles in hanging drop of ovarian cell-conditioned medium to obtain MII oocytes from outbred deer mice. Tissue Engineering Part A 2013; 19: 2626-2637 Read

  1. Agarwal, P., Zhao, S., Bielecki, P., Rao, W., Choi, J.K., Zhao, Y., Yu, J., Zhang, W., and He, X. One-step microfluidic generation of pre-hatching embryo-like core-shell microcapsules for miniaturized 3D culture of pluripotent stem cells. Lab on a Chip 2013; 13: 4525-4533 Read

  1. He, S., Chu, J., Wu, L.-C., Mao, H., Peng, Y., Alvarez-Breckenridge, C.A., Hughes, T., Wei, M., Zhang, J., Yuan, S., Sandhu, S., Vasu, S., Benson (Jr.), D.M., Hofmeister, C., He, X., Ghoshal, K., Devine, S.M., Caligiuri, M.A., and Yu, J. MicroRNAs activate natural killer cells through toll-like receptor signaling. Blood 2013; 121(23): 4663-4671 Read
  2. Choi, J.K. and He, X. In vitro maturation of cumulus-oocyte complexes for efficient isolation of oocytes from outbred deer mice. PLoS ONE 2013; 8(2): e56158 Read

  1. Yu, J., Peng, Y., Wu, L.-C., Xie, Z., Deng, Y., Hughes, T., He, S., Mo, X., Chiu, M., Wang, Q.-E., He, X., Liu, S., Grever, M.R., Chan, K.K., and Liu, Z. Curcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia. PLoS ONE 2013; 8(2): e55934 Read
  2. Zhang, W.^, Zhao, S.^, Rao, W., Snyder, J., Choi, J.K., Wang, J., Khan, I.A., Saleh, N.B., Mohler, P.J., Yu, J., Hund, T.J., Tang, C., and He, X. A novel core-shell microcapsule for encapsulation and 3D culture of embryonic stem cells. Journal of Materials Chemistry B 2013; 1(7): 1002-1009 (^equal contribution) Read

  1. Wang, J., Chen, Y., Yao, K., Wilbon, P.A., Zhang, W., Ren, L., Zhou, J., Nagarkatti, M., Wang, C., Chu, F., He, X., Decho, A.W., and Tang, C. Robust antimicrobial compounds and polymers derived from natural resin acids. Chemical Communications 2012; 48: 916-918 Read
  1. Zhang, W. and He, X. Microencapsulating and banking living cells for cell-based medicine. Journal of Healthcare Engineering 2011; 2: 427-446 Read

  1. Yao, K., Wang, J., Zhang, W., Lee, J.S., Wang, C., Chu, F., He, X., Tang, C. Degradable rosin ester-caprolactone graft copolymers, Biomacromolecules 2011; 12: 2171-2177 Read

  1. He, X. Thermostability of biological systems: Fundamentals, challenges, and quantification. The Open Biomedical Engineering Journal 2011; 5: 47-73 Read

  1. Gilstrap, K., Hu, X., Lu, X., and He, X. Nanotechnology for energy-based cancer therapies. American Journal of Cancer Research 2011; 1(4): 508-520 Read

  1. Zhang, X., Wan, G., Berger, F.G., He, X., and Lu, X. The ATM kinase induces microRNA biogenesis in DNA damage. Molecular Cell 2011; 41: 371-383 Read

  1. Yang, G., Veres, M., Szalai, G., Zhang, A., Xu, L.X., and He, X. Biotransport phenomena in freezing mammalian oocytes. Annals of Biomedical Engineering 2011; 39(1): 580-591 Read

  1. Zhang, W., Gilstrap, K., Wu, L., K.C., R. B., Moss, M. A., Wang, Q., Lu, X., and He, X. Synthesis and characterization of thermally responsive Pluronic F127-chitosan nanocapsules for controlled release and intracellular delivery of small molecules. ACS Nano 2010; 4(11): 6747-6759 Read

  1. Yang, G., Gilstrap, K., Zhang, A., Xu, L.X., and He, X. Collapse temperature of solutions important for lyopreservation of living cells at ambient temperature. Biotechnology and Bioengineering 2010; 106(2): 247-259Read

  1. Zhang, W.^, Yang, G.^, Zhang, A., Xu, L.X., and He, X. Preferential vitrification of water in small (~100 µm) alginate microcapsules significantly augments cell cryopreservation by vitrification. Biomedical Microdevices 2010; 12(1): 89-96 (^equal contribution) Read
  2. Zhang, W., Rong, J, Wang, Q., and He, X. The encapsulation and intracellular delivery of trehalose using a thermally responsive nanocapsule. Nanotechnology 2009; 20(27): Article No. 275101 (14pp) Read

  1. Zhang, W. and He, X. Encapsulation of living cells in small (~100 µm) alginate microcapsules by electrostatic spraying: a parametric study. Journal of Biomechanical Engineering 2009; 131: Article No. 074515 (6pp) Read

  1. Yang, G., Zhang, A., Xu, L.X., and He, X. Modeling the cell type dependence of diffusion-limited intracellular ice nucleation and growth: Implications for cell cryopreservation by both vitrification and slow freezing. Journal of Applied Physics 2009; 105: Art. No. 114701 (11 pp) Read
  2. He, X., Bhowmick, S., and Bischof, J.C. Thermal therapy in urologic systems: A comparison of Arrhenius and thermal isoeffective dose (TID) models in predicting hyperthermic injury. Journal of Biomechanical Engineering 2009; 131: Article No. 074507 (12pp) Read
  3. Li, D. and He, X. Desiccation induced structural alterations in a 66-amino acid fragment of an anhydrobiotic nematode late embryogenesis abundant (LEA) protein. Biomacromolecules 2009; 10: 1469-1477 Read

  1. He, X., Fowler, A., Menze, M., Hand, S., and Toner, M. Desiccation kinetics and biothermodynamics of trehalose solutions in thin films: Implication for lyopreservation. Annals of Biomedical Engineering 2008; 36(8): 1428-1439 Read
  2. He, X., Park, E., Fowler, A., Yarmush, M., and Toner, M. Vitrification by ultra-fast cooling at a low concentration of cryoprotectants in a quartz microcapillary: A study using murine embryonic stem cells. Cryobiology 2008; 56(3): 223-232 Read

  1. Risco, R., Elmoazzen, H., Doughty, M., He, X., and Toner, M. Thermal performance of quartz capillaries for vitrification. Cryobiology 2007; 55(3): 222-229 Read
  2. He, X., Fowler, A., and Toner, M. Water activity and mobility in solutions of glycerol and small molecular weight sugars: Implication for cryo- and lyo- preservation. Journal of Applied Physics 2006; 100 (7): Art. No. 074702 (11 pp) Read
  3. He, X., Amin, A., Fowler A., and Toner, M. Thermally induced introduction of trehalose into primary rat hepatocytes. Cell Preservation Technology 2006; 4(3): 178-187 Read
  4. Aksan, A., Irimia, D., He, X., and Toner, M. Desiccation kinetics of biopreservation solutions in micro-channels. Journal of Applied Physics 2006; 99 (6): Art. No. 064703 (9 pp) Read
  5. He, X. and Bischof, J. C. Analysis of thermal stress in cryosurgery of kidneys. Journal of Biomechanical Engineering2005; 127(4): 656-661 Read
  6. Bischof, J. C. and He, X. Thermal stability of proteins. Annals of the New York Academy of Sciences 2005; 1066: 12-33 Read
  7. He, X. and Bischof, J. C. The kinetics of thermal injury in human renal carcinoma cells. Annals of Biomedical Engineering 2005; 33(4): 502-510 Read
  8. He, X., Wolkers, W. F., Crowe, J. H., Swanlund D. J., and Bischof J. C. In situ thermal denaturation of proteins in dunning AT-1 prostate cancer cells: Implication for hyperthermic cell injury. Annals of Biomedical Engineering2004; 32(10): 1384-1398 Read
  9. He, X., McGee, S., Coad, J. E., Schmidlin, F., Iaizzo, P. A., Swanlund, D. J., Rudie, E., Kluge, S. and Bischof, J. C. Investigation of the thermal and tissue injury behavior in microwave thermal therapy using a porcine kidney model. International Journal of Hyperthermia 2004; 20(6): 567-593 Read

  1. Chao, B. H., He, X., and Bischof, J. C. Pre-existing inflammation induced by TNF-α augments cryosurgical injury on human prostate cancer. Cryobiology 2004; 49(1): 10-27 Read
  2. He, X. and Bischof, J. C. Quantification of temperature and injury in thermal therapy and cryosurgery. Critical Reviews in Biomedical Engineering 2003; 31(5): 355-421 Read
  3. He, X., Zhang, R., Wang, S., Shang, C., and Yu, B. Computational simulation and experimental verification of the refrigeration system in inverter air-conditioners. Heating Ventilation & Air Conditioning 2001; 31: 43-48 Read
  4. He, X., Zhang, R., Wang, S., Shang, C., and Yu, B. Computational simulation and experimental verification of reciprocation type refrigeration compressor. Journal of Beijing University of Technology 2001; 27(1): 104-107 Read
  5. He, X., Wang, Z., and Yu, B. Performance analysis of small capacity inverter air conditioner using a single capillary for throttling. Fluid Machinery 1998; 12: 47-50 Read
  6. Yu, B., Wang, Z., and He, X. Effect of refrigerant charge on the performance of the refrigeration system in inverter air conditioner and its determining principle. Fluid Machinery 1998; 9: 52-56 Read

Books

  1. He, X. and Bischof, J. (Editors) Multiscale Technologies for Cryomedicine-Implementation from Nano to Macroscale. Singapore: World Scientific Publishers/Imperial College Press, 2016; link

Book Chapters

  1. Wang, H. and He, X. Nanoparticles for Targeted Drug Delivery to Cancer Stem Cells and Tumor. In Targeted Drug Delivery: Methods and Protocols, Editors: Sirianni, R.W. and Behkam, B.; Berlin: Springer, pp. 59-67, 2018 link
  2. Huang, H. and He, X. Microscale materials and devices for cell cryopreservation by vitrification. In Multiscale Technologies for Cryomedicine-Implementation from Nano to Macroscale, Editors: He, X. and Bischof, J.; Singapore: World Scientific Publishers/Imperial College Press, pp. 101-124, 2016 link
  3. He, X., Rao, W., and Wang, H. Polymeric nanoparticles for cryobiological applications. In Multiscale Technologies for Cryomedicine-Implementation from Nano to Macroscale, Editors: He, X. and Bischof, J.; Singapore: World Scientific Publishers/Imperial College Press, pp. 277-300, 2016 link
  4. He, X. Preservation of embryonic stem cells. In Methodological Advances in the Culture, Manipulation and Utilization of Embryonic Stem Cells for Basic and Practical Applications, Editor: Atwood, C.; Vienna, Austria: InTech Publisher, pp. 113-138, 2011 Link